Stephanie Lauer

Stephanie smiling outside of Borelli Hall with green trees and brick building in backgroundDr. Lauer received her B.S. in Biology from Rider University in 2010. She completed her Ph.D. in Biology at New York University in 2019, then performed postdoctoral research at NYU Langone. Dr. Lauer uses the budding yeast, Saccharomyces cerevisiae, as a model to understand cell fitness, genome organization, and evolution.

Courses Taught
Dr. Lauer teaches General Biology, Biochemistry, and Genetics.

Research Interests
I combine classic techniques in genetics with cutting-edge methods in genomics, genome engineering, and synthetic biology to understand how cells adapt and evolve. To perform this research, I use the budding yeast, Saccharomyces cerevisiae (italics). While S. cerevisiae (italics) is a microbe, it's also eukaryotic, which means it's an excellent model for understanding more complex organisms and their genomes.

During my graduate work, I studied the role of copy number variants (CNVs) in driving rapid adaptive evolution. CNVs, which include duplications or deletions of genetic material, vary across individuals within a species. I developed a novel fluorescent reporter to detect and track CNVs as they arise in complex evolving populations of yeast. This research sparked my interest in genome structure and organization. As a postdoctoral researcher, I joined an international team of scientists who are creating an entire yeast genome from scratch with new designer features. This endeavor is called the synthetic yeast genome project (Sc2.0).

As the project nears completion, we look forward to using synthetic chromosomes to study important biological questions. Can we manipulate functional elements like the centromere? Can we eliminate all of the introns and the RNA splicing machinery? Can we use the inducible evolution system SCRaMbLE to create yeast cells with new functions? If you're interested in these questions and more, let's discuss research opportunities! Send me an e-mail or stop by my office in Costello 113."